UO DRUG DELIVERY

This Operativie Unit works in drug delivery for precompetitive and industrial research, in a context of good laboratory practices. The studies includes aspects related to the formulation, industrial development and manufacture of medicines

Responsable
Prof.ssa Patrizia Santi
Dipartimento di Farmacia
Viale delle Scienze 27/a - 43124 Parma
e-mail: patrizia.santi@unipr.it
CV

Competences
The skills of this OU is related to pre-formulation and formulation of pharmaceutical dosage forms for oral application, transdermal, ocular, nasal and lung, as well as their evaluation in-vitro.

(Prof. Patrizia Santi):
Trandermica administration of drugs, buccal and ocular administration. Preparation of solid and semi-solid pharmaceutical forms. Evaluation of mechanical properties and bioadhesion of pharmaceutical forms, release and permeation across biological barriers, accumulation in tissues. Physical and chemical enhancement techniques to increase the transport of drugs.

(Prof. Ruggero Bettini)
Pharmaceutical applications of supercritical fluids, solid-state chemistry of materials for pharmaceutical use, controlled release of oral medications, both for human and veterinary drugs, natural polymers for tissue engineering.

(Prof. Paolo Colombo)
Swellable matrices for drug delivery of oral powder for nasal and pulmonary drug delivery and nano

(Prof. Marco Silvestri)
expertis on the mechanisms and systems for the design and control of automated machinery used in the pharmaceutical industry.

(Prof. Alessandro Tasora)
Expertise on issues of granular flow and process technologies.

References
National Progjects (2009-2012)
15-12-2009 / 15-06-2011 Novel anti-malaria therapy in adults and children: application of controlled release technologies. Accordo Mi.S.E.- ICE - CRUI Attuazione 2008, Project n. 071

Patents

  1. R. BETTINI, A. ROMANI, P. SOLIANI
    “Protesi tubulare multistrato per chirurgia ricostruttiva” (Tubular multilayer prosthesis for reconstructive surgery) talian Patent Application n. MI2011A 001905
  2. G. COLOMBO, P. COLOMBO, L. GALLINA, A. SCAGLIARINI, F. SONVICO. “Therapeutic paints based in sucralfate gel for the treatment of skin or mucosa lesions” Application n PCT/EP2008/064528 del 27.10.2008.
  3. F. BUTTINI, P. COLOMBO, C. PARLATI, D. COCCONI, R. MUSA. “Particles comprising a salt of 8-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1h)-quinolinone having improved adhesion properties for powder formulations for inhalation”, Application n PCT/EP2008/169993.6 del 26.11.2008.
  4. R. BETTINI, A. HOCHKOEPPLER, C. MELEGARI, G. PRIMICERI, A. STEFAN
    “Composizioni farmaceutiche con ridotto impatto ambientale”
    Domanda di brevetto Italiano n. MI2012A 001715 depositata il 11.10.2012.
  5. R. BETTINI, A. BIANCHERA, M. CORUZZI, L. ELVIRI
    “Mucoadhesive compositions comprising hyaluronic acid and chitosan for topical application”
    Application number PCT/EP2012/071138 del 25/10/2012

Bibliografia (2010-2012):

Prof. Paolo Colombo

  • Buttini F, Colombo P, Rossi A, Sonvico F, Colombo G. Particles and powders: Tools of innovation for non-invasive drug administration. J Control Release. 2012 Mar 4. [Epub ahead of print]
  • Oliveira PR, Bernardi LS, Strusi OL, Mercuri S, Segatto Silva MA, Colombo P, Sonvico F. Assembled modules technology for site-specific prolonged delivery of norfloxacin Int J Pharm. 2011 Feb 28;405(1-2):90-6.
  • Hascicek C, Rossi A, Colombo P, Massimo G, Strusi OL, Colombo G.Assemblage of drug release modules: effect of module shape and position in the assembled systems on floating behavior and release rate. Eur J Pharm Biopharm. 2011 Jan;77(1):116-21.
  • Casas M, Strusi OL, Jiménez-Castellanos MR, Colombo P. Tapioca starch graft copolymers and Dome Matrix® modules II. Effect of modules assemblage on riboflavin release kinetics. Eur J Pharm Biopharm. 2011 Jan;77(1):111-5.
  • Strusi OL, Barata P, Traini D, Young PM, Mercuri S, Colombo G, Sonvico F, Bettini R, Colombo P. Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products. J Control Release. 2010 Aug 17;146(1):54-60.
  • Casas M, Strusi OL, Jiménez-Castellanos MR, Colombo P. Tapioca starch graft copolymers and Dome Matrix modules assembling technology. I. Effect of module shape on drug release. Eur J Pharm Biopharm. 2010 May;75(1):42-7.
  • Senyiğit T, Sonvico F, Barbieri S, Ozer O, Santi P, Colombo P Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin. J Control Release. 2010 Mar 19;142(3):368-73.
  • Raffin RP, Colomé LM, Hoffmeister CR, Colombo P, Rossi A, Sonvico F, Colomé LM, Natalini CC, Pohlmann AR, Costa TD, Guterres SS. Pharmacokinetics evaluation of soft agglomerates for prompt delivery of enteric pantoprazole-loaded microparticles. Eur J Pharm Biopharm. 2010 Feb;74(2):275-80.
  • de Haan BJ, Rossi A, Faas MM, Smelt MJ, Sonvico F, Colombo P, de Vos P. Structural surface changes and inflammatory responses against alginate-based microcapsules after exposure to human peritoneal fluid. J Biomed Mater Res A. 2011 Sep 1;98(3):394-403.

  • Prof. Patrizia Santi

    • Stratum corneum distribution of lidocaine, assessed by tape stripping, from a new bioadhesive transdermal film, C. Padula, A. Fulgoni, P. Santi, Skin Res. and Technol., 16, 125-130 (2010).
    • Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of sumatriptan succinate, C. Balaguer-Fernández, C. Padula, A. Femenía-Font, V. Merino, P. Santi, A. López-Castellano, Drug Delivery, 17 (2), 83-91 (2010).
    • Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin, T. Senyigit, F. Sonvico, S. Barbieri, O. Ozer, P. Santi. P. Colombo, J. Control. Release, 142, 368-373 (2010).
    • Effect of lipopeptides and iontophoresis on acyclovir skin delivery, S. Nicoli, M. Eeman, M. Degeu, E. Bresciani, C. Padula, P. Santi, J. Pharm. Pharmacol., 62, 702-708 (2010).
    • Bioadhesive films containing benzocaine: correlation between in vitro permeation and in vivo local anesthetic effect, D. R. de Araujo, C. Padula, C. M. S. Cereda, G. R. Tófoli, R. Barbosa Brito Júnior, E. de Paula, S. Nicoli, P. Santi, Pharm. Res., 27, 1677-1686 (2010).
    • In vitro permeation of bevacizumab through human sclera: effect of iontophoresis application, S. Pescina, G. Ferrari, P. Govoni, C. Macaluso, C. Padula, P. Santi, S. Nicoli, J. Pharm. Pharmacol., 62(9), 1189-1194 (2010).
    • Single Layer Transdermal Film Containing Lidocaine: Water and Lidocaine Mobility Determined using Neutron Scattering, C. Padula, C. Chiapponi, M.T. Dibari, A. Deriu, F. Sonico, S. Barbieri, J. Ollivier, P. Santi, J. Pharm. Sci., 99(10), 4277-4284 (2010).
    • Combined patch containing salicylic acid and nicotinamide: role of drug interaction, C. Padula, C. Ferretti, S. Nicoli, P. Santi, Current Drug Delivery, 7, 415-420 (2010).
    • Deoxycholate hydrogels of betamethasone-17-valerate intended for topical use: in vitro and in vivo evaluation, T. Şenyiğit, I. Tekmen, P. Santi, Ö. Özen, Int. J. Pharm, 403, 123-129 (2011)

    Prof. Ruggero Bettini

    • M. Vigliano, A: Bianchera, R. Bettini, L. Elviri
      "Determination of Hyaluronic Acid in a Chitosan-Based Formulations by RP C18 and HILIC LC-ESI-MS: an Evaluation of Matrix Effect”
      Chromatographia, 76 (2013) 1761-1766
    • C. Bresciani, G. Morini , R. Bettini , E. Bigliardi, F. Di Ianni , C.S. Cabassi, A. Sabbioni, E. Parmigiani
      “Reproductive efficiency of a new modified boar semen extender for liquid storage”
      Livestock Science 157 (2013) 384-388.
    • F. Zani, C. Veneziani, E. Bazzoni, L. Maggi, G. Caponetti, R. Bettini
      “Sterilization of corticosteroids for ocular and pulmonary delivery with supercritical carbon dioxide”
      Int. J. Pharm. 450 (2013) 218-224
    • A. A. Romani, L. Ippolito, F. Riccardi, S. Pipitone, M. Morganti, M. C. Baroni, A. F. Borghetti, R. Bettini
      “In Vitro Blood Compatibility of Novel Hydrophilic Chitosan Films for Vessel Regeneration and Repair”
      in Advances in Biomaterials Science and Biomedical Applications, R. Pignatello (Ed.) InTech (2013) DOI:10.5772/52706 ISBN: 978-953-51-1051-4
    • F. Menichini , R. Tundis , M. Bonesi , B. de Cindio , M. R Loizza , F. Conforti, G. A. Statti , R. Menabeni , R. Bettini, F. Menichini “Chemical composition and bioactivity of Citrus medica L. cv. Diamante essential oil obtained by hydrodistillation, cold-pressing and Supercritical Carbon Dioxide extraction” Natural Product Research, 25 (2011) 789-799
    • O.L. Strusi, P. Barata, D. Traini, P.M. Young, S. Mercuri, G. Colombo, F. Sonico, R. Bettini, P. Colombo Artesunate-clyndamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products J. Controlled Release 146 (2010) 54-60
    • M. B. Pranzo, D. Cruickshank, M. Coruzzi, M. R. Caira, R. Bettini “Enantiotropically related albendazole polymorphs” J. Pharm. Sci, 99 (2010) 3731-3742
    • R. Bettini, R. Menabeni, R. Tozzi, M.B. Pranzo, I. Pasquali, M. R. Chierotti, R. Gobetto, L. Pellegrino “Didanosine polymorphism in a supercritical antisolvent process” J. Pharm. Sci, 99,1855-1870 (2010)

    Subunit: Crystallization and characterization of solid phases and polymorphs

    Competences:
    This subunit is devoted to crystallization techniques and to the corresponding structural characterization: determination of the crystal structure and of the absolute molecular conformation, singling out and definition of polymorphic, hydrated or solvated forms.

    (Prof. Alessia Bacchi:)
    Crystallization and characterization of molecular structure and crystalline form of drugs with reference to the individuation of polymorphs, solvate and co-crystals. Techniques of X-ray diffraction on single crystal and on powders, also at non-ambient conditions.

    (Prof. Alberto Girlando)
    Characterization of organic molecular crystals, with different optical spectroscopy methods. Particular expertise is on micro-Raman spectroscopy in the Tera-Hertz spectral region for the quick identification of polymorphs, also as a function of temperature or high pressure.

    Recent references
    Prof. Alessia Bacchi

  • M. Carcelli, A. Bacchi, P. Pelagatti, G. Rispoli, D. Rogolino, T. W. Sanchez, M. Sechi, N. Neamati (2013). Ruthenium Arene Complexes as HIV-1 Integrase Strand Transfer Inhibitors. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 118, p. 74-82
  • A. Bacchi (2012). X-ray diffraction as a tool in the path from the design of an active pharmaceutical ingredient to the tablet on the shelf. ATTI DELLA ACCADEMIA NAZIONALE DEI LINCEI. RENDICONTI LINCEI. MATEMATICA E APPLICAZIONI, p. 1-6, ISSN: 1720-0768
  • A. Bacchi, G. Cantoni, D. Cremona, P. Pelagatti, F. Ugozzoli (2011). Exploration of supramolecular synthons and molecular recognition starting from macroscopic measurements of crystal dimensions. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, vol. 123, p. 3256-3259
  • A. BACCHI, M. CARCELLI, C. COMPARI, E. FISICARO, N. PALA, G. RISPOLI, D. ROGOLINO, T.W. SANCHEZ, M. SECHI, V. SINISI, N. NEAMATI (2011). Investigating the Role of Metal Chelation in HIV-1 Integrase Strand Transfer Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, p. 8407-8420
  • A. BACCHI, M. CARCELLI, T. CHIODO, F. MEZZADRI, F. NESTOLA, A. ROSSI (2009). Inclusion Properties, Polymorphism and Desolvation Kinetics in a New 2-Pyridyl Iminophenol Compound with 1D Nanochannels. CRYSTAL GROWTH & DESIGN, vol. 9, p. 3749-3758
  • BACCHI A., MAURO CARCELLI, GIANCARLO PELIZZI (2008). Sampling rifamycin conformational variety by cruising through crystal forms: implications for polymorph screening and for biological models. NEW JOURNAL OF CHEMISTRY, vol. 32, p. 1725-1735

  • Prof. Alberto Girlando

  • A. Girlando, M. Masino, S. Kaiser, Y. Sun, N. Drichko, M. Dressel, H. Mori - Spectroscopic characterization of charge order fluctuations in BEDT-TTF metals and superconductors - Phys. Status Solidi B 249, 953 (2012)
  • A. Girlando, M. Masino, I. Bilotti, A. Brillante, R. G. Della Valle, E. Venuti - Phonon dynamics and electron-phonon coupling in pristine picene - Phys. Chem. Chem. Phys. 14, 1694 (2012)
  • A. Girlando, L. Grisanti, M. Masino, A. Brillante, R. G. Della Valle, E. Venuti - Interaction of charge carriers with lattice and molecular phonons in crystalline pentacene- J. Chem. Phys. 135, 084701 (2011)
  • A. Bacchi, G. Cantoni, M. R. Chierotti, A. Girlando, R. Gobetto, G. Lapadula, P. Pelagatti, A. Sironi, M. Zecchini - Water vapour uptake and extrusion by a crystalline metallorganic solid based on half-sandwich Ru(II) building-blocks - CrystEngComm, 13, 4365 (2011)
  • A. Girlando, L. Grisanti, M. Masino, I. Bilotti, A. Brillante, R. G. Della Valle, E. Venuti - Peierls and Holstein carrier-phonon coupling in crystalline rubrene - Phys. Rev. B 82, 035208 (2010).
  • A. Girlando, S. Ianelli, I. Bilotti, A. Brillante, R. G. Della Valle, E. Venuti, M. Campione, S. Mora, L. Silvestri, P. Spearman, S. Tavazzi - Spectroscopic and structural characterization of two polymorphs of 1,1,4,4-Tetraphenyl-1,3-butadiene. - Crystal Growth & Design 10, 2752- 2758 (2010).
  • S. Tavazzi, L. Silvestri, L. Miozzo, A. Papagni, P. Spearman, S. Ianelli, A. Girlando, A. Camposeo, M. Polo, D. Pisignano - Polarized absorption, spontaneous and stimulated blue light emission of J-type tetraphenylbutadiene monocrystals - ChemPhysChem. 11, 429- 434 (2010).